教員紹介
ACADEMICIAN
木村 博一 KIMURA Hirokazu
- 医療技術学部 臨床工学科
教授
- 研究分野
微生物学・感染症学・生体防御学
- 学位
博士（工学）
大学院
保健科学研究科 保健科学専攻
特別研究指導教員
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博士前期課程
公衆衛生学領域感染症疫学・感染制御学
先端病原体ゲノム解析法（シークエンス法及びメタゲノム解析法など）を基盤とした分子疫学解析法について学びます。また、病原体抗原遺伝子配列に、先駆的in silico解析を加え、感染症の原因究明、ワクチン開発のみならず、集団感染事例における感染源の特定などに関する解析手法論についても学びます。
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博士後期課程
医療科学領域医療科学特別研究/生体分子・病原体遺伝子
細菌の薬剤耐性遺伝子、呼吸器ウイルス（RSウイルス・ヒトライノウイルスなど）および下痢症ウイルス（ノロウイルス・ロタウイルスなど）の遺伝学的解析を基盤とした研究指導を行います。また、ベイジアン・スカイラインプロット法によるウイルス遺伝子型別流行予測プログラムの開発に関する研究指導も行います。
研究や大学院進学についての質問・相談などを受付けています。
経歴
学歴
2000年 群馬大学大学院工学研究科博士後期課程修了・学位取得 [博士(工学)]
職歴
1984年～1992年 群馬県立小児医療センター・心臓血管センター検査課
1992年～2006年 群馬県衛生環境研究所（調査研究グループリーダー）
2006年～2017年8月 国立感染症研究所感染症疫学センター第6室長
2017年9月～2022年3月 群馬パース大学保健科学部検査技術学科 教授
2018年4月～ 群馬パース大学大学院保健科学研究科医療科学領域 教授
2020年4月～ 群馬パース大学大学院保健科学研究科長補佐
2020年4月～ 群馬パース大学附属研究所先端医療科学研究センター長
2022年4月～ 群馬パース大学医療技術学部臨床工学科教授
2023年4月～ 群馬パース大学医療技術学部長補佐
2016年4月～ 横浜市立大学医学部客員教授（医学科ウイルス学兼担）
2017年4月～ 群馬大学医学部客員教授（医学科ウイルス学兼担）
2020年4月～ 日本大学理工学研究科客員教授
2020年1月～ 認定ICD（Infection Control Doctor)
研究内容
病原体（ウイルス・細菌）の進化に関する研究を行っています。また、感染症の重症化の機構解明や病原体検査法の開発に関する研究も行っています。
研究実績詳細
(1) Shirai T, Akagawa M, Makino M, Ishii M, Arai A, Nagasawa N, Sada M, Kimura R, Okayama K, Ishioka T, Ishii H, Hirai S, Ryo A, Tomita H, Kimura H. Molecular Evolutionary Analyses of the Pseudomonas-Derived Cephalosporinase Gene. Microorganisms. 2023 Mar 1;11(3):635. doi: 10.3390/microorganisms11030635. PMID: 36985209; PMCID: PMC10057138.
(2) Akagawa M, Shirai T, Sada M, Nagasawa N, Kondo M, Takeda M, Nagasawa K, Kimura R, Okayama K, Hayashi Y, Sugai T, Tsugawa T, Ishii H, Kawashima H, Katayama K, Ryo A, Kimura H. Detailed Molecular Interactions between Respiratory Syncytial Virus Fusion Protein and the TLR4/MD-2 Complex In Silico. Viruses. 2022 Oct 28;14(11):2382. doi: 10.3390/v14112382. PMID: 36366480; PMCID: PMC9694959.
(3) Miyakawa K, Nishi M, Ogawa M, Matsunaga S, Sugiyama M, Nishitsuji H, Kimura H, Ohnishi M, Watashi K, Shimotohno K, Wakita T, Ryo A. Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins. Nat Commun. 2022 Jan 27;13(1):531. doi: 10.1038/s41467-022-28171-5. PMID: 35087074; PMCID: PMC8795376.
(4) Saito M, Tsukagoshi H, Sada M, Sunagawa S, Shirai T, Okayama K, Sugai T, Tsugawa T, Hayashi Y, Ryo A, Takeda M, Kawashima H, Saruki N, Kimura H. Detailed Evolutionary Analyses of the F Gene in the Respiratory Syncytial Virus Subgroup A. Viruses. 2021 Dec 15;13(12):2525. doi: 10.3390/v13122525. PMID: 34960794; PMCID: PMC8706373.
(5) Kawata Y, Hirano H, Takahashi R, Miyano Y, Kimura A, Sato N, Morita Y, Kimura H, Fujita K. Detailed Structure and Pathophysiological Roles of the IgA-Albumin Complex in Multiple Myeloma. Int J Mol Sci. 2021 Feb 10;22(4):1766. doi: 10.3390/ijms22041766. PMID: 33578917; PMCID: PMC7916671.
(6) Kimura H, Kurusu H, Sada M, Kurai D, Murakami K, Kamitani W, Tomita H, Katayama K, Ryo A. Molecular pharmacology of ciclesonide against SARS-CoV-2. J Allergy Clin Immunol. 2020 Aug;146(2):330-331. doi: 10.1016/j.jaci.2020.05.029. Epub 2020 Jun 13. PMID: 32593491; PMCID: PMC7293530.
(7) Aso J, Kimura H, Ishii H, Saraya T, Kurai D, Nagasawa K, Matsushima Y, Ryo A, Takizawa H. Molecular evolution of the hemagglutinin-neuraminidase (HN) gene in human respirovirus 3. Virus Res. 2020 Feb; 277:197824. doi: 10.1016/j.virusres.2019.197824. Epub 2019 Nov 26. PMID: 31783038.
(8) Ozaki K, Matsushima Y, Nagasawa K, Aso J, Saraya T, Yoshihara K, Murakami K, Motoya T, Ryo A, Kuroda M, Katayama K, Kimura H. Molecular Evolution of the Protease Region in Norovirus Genogroup II. Front Microbiol. 2020 Jan 14; 10:2991. doi: 10.3389/fmicb.2019.02991. PMID: 31993031; PMCID: PMC6971112.
(9) Miyakawa K, Matsunaga S, Yokoyama M, Nomaguchi M, Kimura Y, Nishi M, Kimura H, Sato H, Hirano H, Tamura T, Akari H, Miura T, Adachi A, Sawasaki T, Yamamoto N, Ryo A. PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation. Nat Commun. 2019 Apr 23;10(1):1844. doi:10.1038/s41467-019-09867-7. PMID: 31015445; PMCID: PMC6479052.
(10) Kimura H, Shirabe K, Takeda M, Kobayashi M, Tsukagoshi H, Okayama K, Ryo A, Nagasawa K, Okabe N, Minagawa H, Kozawa K. The association between documentation of Koplik spots and laboratory diagnosis of measles and other rash diseases in a national measles surveillance programme in Japan. Front Microbiol. 2019 Feb 18; 10:269. doi: 10.3389/fmicb.2019.00269. PMID: 30833942; PMCID: PMC6387930.
(11) Sakon N, Sadamasu K, Shinkai T, Hamajima Y, Yoshitomi H, Matsushima, Takada R, Terasoma F, Nakamura A, Komano J, Nagasawa K, Shimizu H, Katayama K, Kimura H. Foodborne outbreaks caused by human norovirus GII.P17- GII.17-contaminated nori Japan ,2017. Emerg Infect Dis. 2018 May;24(5):920-923.
doi: 10.3201/eid2405.171733. PMID: 29664371; PMCID: PMC5938760.
(12) Nagasawa K, Matsushima Y, Motoya T, Mizukoshi F, Ueki Y, Sakon N, Murakami K, Shimizu T, Okabe N, Nagata N, Shirabe K, Shinomiya H, Suzuki W, Kuroda M, Sekizuka T, Ryo A, Fujita K, Oishi K, Katayama K, Kimura H. Phylogeny and immunoreactivity of norovirus GII.P16-GII.2, Japan, winter 2016-17. Emerg Infect Dis. 2018 Jan;24(1):144-148. doi: 10.3201/eid2401.170284. PMID: 29260675; PMCID: PMC5749477.
(13) Motoya T, Nagasawa K, Matsushima Y, Nagata N, Ryo A, Sekizuka T, Yamashita A, Kuroda M, Morita Y, Suzuki Y, Sasaki N, Katayama K, Kimura H. Molecular evolution of the VP1 gene in human norovirus GII.4 variants in 1974–2015. Front Microbiol. 2017 Dec 5; 8:2399. doi: 10.3389/fmicb.2017.02399. PMID: 29259596; PMCID: PMC5723339.
(14) Miyakawa K, Nishi M, Matsunaga S, Okayama A, Anraku M, Kudoh A, Hirano H, Kimura H, Morikawa Y, Yamamoto N, Ono A, Ryo A. The tumor suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein. Nat Commun. 2017 Jan 30; 8:14259. doi: 10.1038/ncomms14259. PMID: 28134256; PMCID: PMC5290283.
(15) Kimura H, Nagasawa K, Tsukagoshi H, Matsushima Y, FujitaK, Yoshida LY, Tanaka R, Ishii H, Shimojo N, Kuroda M, Ryo A. Molecular evolution of the fusion protein gene in human respiratory syncytial virus subgroup A. Infect Genet Evol. 2016 Sep;43:398-406. doi: 10.1016/j.meegid.2016.06.019. Epub 2016 Jun 9. PMID: 27291709.
(16) Kobayashi M, Matsushima Y, Motoya T, Sakon N, Shigemoto N, Okamoto-Nakagawa R, Nishimura K, Yamashita Y, Kuroda M, Saruki N, Ryo A, Saraya T, Morita Y, Shirabe K, Ishikawa M, Takahashi T, Shinomiya H, Okabe N, Nagasawa K, Suzuki Y, Katayama K, Kimura H. Molecular evolution of the capsid gene in human norovirus genogroup II. Sci Rep. 2016 Jul 7;6:29400. doi: 10.1038/srep29400. PMID: 27384324; PMCID: PMC4935990.
(17)Sugai K, Kimura H, Miyaji Y, Tsukagoshi H, Yoshizumi M, Sasaki-Sakamoto T, Matsunaga S, Yamada Y, Kashiwakura J, Noda M, Ikeda M, Kozawa K, Ryo A, Yoshihara S, Ogata H, Okayama Y. MIP-1α level in nasopharyngeal aspirates at the first wheezing episode predicts recurrent wheezing. J Allergy Clin Immunol. 2016 Mar;137(3):774-781. doi: 10.1016/j.jaci.2015.08.032. Epub 2015 Oct 19. PMID: 26494023.
(18) Matsushima Y, Ishikawa M, Shimizu T, Komane A, Kasuo S, Shinohara M, Nagasawa K, Kimura H, Ryo A, Okabe N, Haga K, Doan YH, Katayama K, Shimizu H. Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region. Euro Surveill. 2015 Jul 2;20(26):21173. doi:10.2807/1560-7917.es2015.20.26.21173. PMID: 26159307.
(19) Kimura H, Saitoh M, Kobayashi M, Ishii H, Saraya T, Kurai D, Tsukagoshi H, Shirabe K, Nishina A, Kozawa K, Kuroda M, Takeuchi F, Sekizuka T, Minakami H, Ryo A, Takeda M. Molecular evolution of haemagglutinin (H) gene in measles virus. Sci Rep. 2015 Jul 1; 5:11648. doi: 10.1038/srep11648. PMID: 26130388; PMCID: PMC4486977.
(20) Miyakawa K, Matsunaga S, Kanou K, Matsuzawa A, MorishitaR, Kudoh A, Shindo K, Yokoyama M, Sato H, Kimura H, Tamura T, Yamamoto N, Ichijo H, Takaori-Kondo A, Ryo A. ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction. Nat Commun. 2015 Apr 22; 6:6945. doi: 10.1038/ncomms7945. PMID: 25901786; PMCID: PMC4423214.
(21) Kuroda M, Niwa S, Sekizuka T, Tsukagoshi H, Yokoyama M, Ryo A, Sato H, Kiyota N, Noda M, Kozawa K, Shirabe K, Kusaka T, Shimojo N, Hasegawa S, Sugai K, Obuchi M, Tashiro M, Oishi K, Ishii H, Kimura H. Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C. Sci Rep. 2015 Feb 2; 5:8185. doi: 10.1038/srep08185. PMID: 25640899; PMCID: PMC4313092.
(22) Kobayashi M, Takayama I, Kageyama T, Tsukagoshi H, Saitoh M, Ishioka T, Yokota Y, Kimura H, Tashiro M, Kozawa K. Novel reassortant influenza A(H1N2) virus derived from A(H1N1) pdm09 virus isolated from swine, Japan, 2012. Emerg Infect Dis. 2013 Dec;19(12):1972-1974. doi: 10.3201/eid1912.120944. PMID: 24274745; PMCID: PMC3840884.
(23) Mizuta K, Yamakawa T, Nagasawa H, Itagaki T, Katsushima F, Katsushima Y, Shimizu Y, Ito S, Aokia Y, Ikeda T, Abiko C, Kuroda M, Noda M, Kimura H, Ahiko T. Epidemic myalgia associated with human parechovirus type 3 infection among adults occurs during an outbreak among children: Findings from Yamagata, Japan, in 2011. J Clin Virol. 2013 Sep;58(1):188-193. doi: 10.1016/j.jcv.2013.05.019. Epub 2013 Jun 20. PMID: 23791478.
(24) Saraya T, Mikoshiba M, Kamiyama H, Yoshizumi M, Tsuchida S, Tsukagoshi H, Ishioka T, Terada M, Tanabe E, Tomioka C, Ishii H, Kimura H, Kozawa K, Shiohara T, Takizawa T, Goto T. Evidence for reactivation of human herpesvirus 6 in generalized lymphadenopathy in a patient with drug-induced hypersensitivity syndrome. J Clin Microbiol. 2013 Jun;51(6):1979-1982. doi: 10.1128/JCM.00097-13. Epub 2013 Mar 27. PMID: 23536404; PMCID: PMC3716082.
(25) Sakano C, Kuroda M, Sekizuka T, Ishioka T, Morita Y, Ryo A, Tsukagoshi H, Kawai Y, Inoue N, Takada H, Ogaswara Y, Nishina A, Shimoda MA, Kozawa K, Oishi K, Kimura H. Genetic analysis of non-hydrogen sulfide-producing Salmonella enterica serovar typhimurium and S. enterica serovar infantis isolates in Japan. J Clin Microbiol. 2013 Jan;51(1):328-330. doi: 10.1128/JCM.02225-12. Epub 2012 Nov 7. PMID: 23135931; PMCID: PMC3536232.
(26) Okazaki K, Kusaka T, Kondo M, Kozawa K, Yoshizumi M, Kimura H. Temporal alteration of serum G-CSF and VEGF levels in perinatal asphyxia treated with head cooling. Cytokine. 2012 Dec;60(3):812-814. doi: 10.1016/j.cyto.2012.08.001. Epub 2012 Sep 1. PMID: 22944463.
(27) Mizuta K, Kuroda M, Kurimura M, Yahata Y, Sekizuka T, Aoki Y, Ikeda T, Abiko C, Noda M, Kimura H, Mizutani T, Kato T, Kawanami T, Ahiko T. Epidemic myalgia in adults associated with human parechovirus type 3 infection, Yamagata, Japan, 2008. Emerg Infect Dis. 2012 Nov;18(11):1787-1793. doi: 10.3201/eid1811.111570. PMID: 23095469; PMCID: PMC3559140.
(28) Miyakawa K, Sawasaki T, Matsunaga S, Tokarev A, Quinn G, Kimura H, Nomaguchi M, Adachi A, Yamamoto N, Guatelli J, Ryo A. Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu. Sci Signal. 2012 Oct 9;5(245):ra73. doi:10.1126/scisignal.2003212. PMID: 23047923.
(29) Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Sam W, Lee SW, Ryo A. A distinct role for Pin1 in the induction and maintenance of pluripotency. J Biol Chem. 2011 Apr 1;286(13):11593-11603. doi: 10.1074/jbc.M110.187989. Epub 2011 Feb 4. PMID: 21296877; PMCID: PMC3064213.
(30) Mizuta K, Hirata A, Suto A, Aoki Y, Ahiko T, Itagaki T, Tsukagoshi H, Morita Y, Obuchi M, Akiyama M, Okabe N, Noda M, Tashiro M, Kimura H. Phylogenetic and cluster analysis of human rhinovirus species A (HRV-A) isolated from children with acute respiratory infections in Yamagata, Japan. Virus Res. 2010 Feb;147(2):265-274. doi: 10.1016/j.virusres.2009.11.011. Epub 2009 Nov 27. PMID: 19945490.
(31) Hishinuma-Igarashi I, Mizuta K, Saito Y, Ohuchi Y, Noda M, Akiyama M, Sato H, Tsukagoshi H, Okabe N, Tashiro M, Kimura H. Phylogenetic analysis of human bocavirus (HBoV) detected from children with acute respiratory infection in Japan. J Infect. 2009 Apr;58(4):311-313. doi: 10.1016/j.jinf.2009.02.007. Epub 2009 Mar 17. PMID: 19282032.
(32) Yamaguchi T, Kimura H, Kurabayashi M, Kozawa K, Kato M. Interferon-gamma enhances human eosinophil effector functions induced by granulocyte-macrophage colony-stimulating factor or interleukin-5. Immunol Lett. 2008 Jun 15;118(1):88-95. doi: 10.1016/j.imlet.2008.03.005. Epub 2008 Apr 10. PMID: 18440651.
(33) Okazaki K, Kondo M, Kato M, Kakinuma R, Nishida A, Noda M, Taniguchi K, Kimura H. Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. Pediatrics. 2008 Apr;121(4):e748-753. doi: 10.1542/peds.2007-1697. Epub 2008 Mar 17. PMID: 18346989.
(34) Hansman GS, Oka T, Okamoto R, Nishida T, Toda S, Noda M, Sano D, Ueki Y, Imai T, Omura T, Nishio O, Kimura H, Takeda N. Human sapovirus in clams, Japan. Emerg Infect Dis. 2007 Apr;13(4):620-622. doi: 10.3201/eid1304.061390. PMID: 17553282; PMCID: PMC2725984.
(35) Kobayashi T, Kimura H, Okada Y, Inoue Y, Shinohara M, Kobayashi T, Morikawa A. Increased CD11b expression on polymorphonuclear leucocytes and cytokine profiles in patients with Kawasaki disease. Clin Exp Immunol. 2007 Apr;148(1):112-118. doi: 10.1111/j.1365-2249.2007.03326. x. PMID: 17286760; PMCID: PMC1868857.
(36) Nishina A, Kimura H, Sekiguchi A, Fukumoto R, Nakajima S, Furukawa S. Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK. J Lipid Res. 2006 Jul;47(7):1434-1443. doi: 10.1194/jlr.M600045-JLR200. Epub 2006 Apr 13. PMID: 16614393.
(37) Kato M, Yamaguchi T, Tachibana A, Suzuki M, Izumi T, Maruyama K, Hayashi Y, Kimura H. An atypical protein kinase C, PKC zeta, regulates human eosinophil effector functions. Immunology. 2005 Oct;116(2):193-202. doi: 10.1111/j.1365-2567.2005.02210.x. PMID: 16162268; PMCID: PMC1817821.
(38) Wada T, Toma T, Okamoto H, Kasahara Y, Koizumi S, Agematsu K, Kimura H, Shimada A, Hayashi Y, Kato M, Yachie Y. Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency. Blood. 2005 Sep 15;106(6):2099-2101. doi: 10.1182/blood-2005-03-0936. Epub 2005 Apr 21. PMID: 15845893.
(39) Okada Y, Minakami H, Tomomasa T, Kato M, Inoue Y, Kozawa K, Kimura H, Morikawa A. Serum procalcitonin concentration in patients with Kawasaki disease. J Infect. 2004 Feb;48(2):199-205. doi: 10.1016/j.jinf.2003.08.002. PMID: 14720497.
(40) Shimada A, Maruyama K, Shitara T, Kato M, Cho K, Kobayashi T, Fujiu T, Tsuchida Y, Nishida A, Hayashi Y, Minakami H, Kozawa K, Kimura H. Proinflammatory cytokinemia associated with transient myeloproliferative disorder in down syndrome. Biol Neonate. 2004;85(3):167-172. doi: 10.1159/000075376. Epub 2003 Dec 10. PMID: 14671434.
その他
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【主な学会活動】
Frontiers in Microbiology (Associate Editor)
Frontiers in Plant Science (Associate Editor)
Microorganisms (Academic Editor)
BMC Infectious Diseases (Associate Editor)
Infection Genetics and Evolution (Handling Editor)
Gut Pathogens (Associate Editor)
Journal of Clinical Virology (Editor Board Members)
日本ウイルス学会（ウイルス検査体制委員会委員）
日本感染症学会
日本医学検査学会
